Erythema multiforme is divided into major and minor forms and is now regarded as distinct from Stevens–Johnson syndrome (SJS) and toxic epidermal. dermal necrolysis, where erythema multiforme minor is the mildest type .. Gavaldá-Esteve C, Murillo-Cortés J, Poveda-Roda R. Eritema multiforme. Revisión y. Find out about erythema multiforme, a skin reaction that usually causes a rash for a few weeks.

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Erythema multiforme: MedlinePlus Medical Encyclopedia

This is believed to be nearly always due to HSV-1 infection. Herpes simplex virus suppression and even prophylaxis with acyclovir has been shown to prevent recurrent erythema multiforme eruption.

Aphthous stomatitis oral candidiasis lichen planus leukoplakia pemphigus vulgaris mucous membrane pemphigoid cicatricial pemphigoid herpesvirus coxsackievirus syphilis systemic minot squamous-cell carcinoma. Many drugs have been reported to trigger erythema multiforme, including barbiturates, non-steroidal anti- inflammatory drugspenicillinssulphonamides, phenothiazines and anticonvulsants.

There is a male predominance. Sokumbi O, Wetter DA. Symptoms include fever, malaise, sore throat, cough, vomiting, diarrhea, arthralgia, and minot. Urticaria and erythema L50—L54, Although access to this website is not restricted, the information found here is intended for use by medical providers.

Systemic steroids have been suggested as adjuvant therapy based on their immunosuppressant effects. It varies with the age of the lesionits appearance, and which part is biopsied. Drug Reactions Read more. Irritation or even pressure from clothing will cause the erythema sore to continue to expand along its margins for weeks or months, long after the original sore at the center heals. The single most common trigger for developing erythema multiforme is herpes multiflrme virus HSV infectionusually herpes labialis cold sore on the lip and less often genital herpes.


Erythema annulare centrifugum Erythema marginatum Erythema migrans Erythema gyratum repens. Your provider minot have you stop taking any medicines that may be causing the problem. Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme.

Erythema multiforme – Wikipedia

Patients should address specific medical concerns with their physicians. Polymorph erythemaerythema, polymorphErythema multiforme. Related Bing Images Extra: Erythema multiforme and related disorders. Target lesions are a typical manifestation. Self-skin examination New smartphone apps to check your skin Learn more Sponsored content.

Freckles lentigo melasma nevus melanoma. The condition varies from a mild, self-limited rash E. Erythema multiforme is often linked to the herpes simplex virus the virus that causes cold sores. Erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis in children: Definition NCI A systemic, serious, and life-threatening disorder mhltiforme by erythematous and necrotic lesions in the skin and mucous membranes that are associated with bullous detachment of the epidermis.

D ICD – The patient may have difficulty speaking or swallowing due to pain. Disease or Syndrome T Footnotes Competing interests None declared.

The role of oral corticosteroids remains controversial, as no controlled studies have shown any benefit. By using this site, you agree to the Terms of Use and Privacy Policy. The syndrome minnor thought to be a hypersensitivity complex affecting the skin and the mucous membranes.

Erythema Multiforme

Erythema multiforme may come back again recurespecially if you get re-exposed to whatever caused it in the first erirema. People with EM often have family members who have had EM as well.


The first line of treatment for EM is removal of the inciting factor when possible. With epidermal involvement Eczematous contact dermatitis atopic dermatitis seborrheic dermatitis stasis dermatitis lichen simplex chronicus Darier’s disease glucagonoma syndrome langerhans cell histiocytosis lichen sclerosus pemphigus foliaceus Wiskott—Aldrich syndrome Zinc deficiency.

Episodic angioedema with eosinophilia Hereditary angioedema. Differentiating EM and Stevens-Johnson syndrome Although previously thought to be on a similar continuum of EM, and histologically appearing the same, 1 Stevens-Johnson syndrome SJS is increasingly being considered a separate disease process.

It is considered a continuum of Toxic Epidermal Necrolysis. Started inthis collection now contains interlinked topic pages divided into a tree of 31 specialty books and chapters.

For cases in which Mycoplasma infection is suspected to be the cause, treatment recommendations include a macrolide or tetracycline. Individuals with persistent chronic erythema multiforme will often have a lesion form at an injury site, e. The mild form usually presents with mildly itchy but itching can be very severepink-red blotches, symmetrically arranged and starting on the extremities. The herpes infection usually precedes the skin eruption by 3—14 days.

In most cases, it occurs in response to an infection.

Pathophysiology Severe clinical variant of Erythema Multiforme Previously thought to be part of same spectrum as Erythema Multiforme Minor Now thought to be clinically distinct.